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Beilstein J. Org. Chem. 2015, 11, 739–747, doi:10.3762/bjoc.11.84
Graphical Abstract
Figure 1: The structure of galectin-1. Reproduced with permission from [21]. Copyright 2004 Elsevier.
Figure 2: (a) Generation 2 PAMAM dendrimer. (b) Lactose-functionalized dendrimers 1–4. Color-coding correspon...
Figure 3: Average diameter (nm) of multivalent galectin-1 nanoparticles formed with multivalent glycodendrime...
Figure 4: Representative fluorescent micrographs of glycodendrimer mediated galectin-1 nanoparticles. Nanopar...
Figure 5: Comparison of average nanoparticle diameter (nm) formed with 4 measured by FM (blue) and DLS (diago...
Figure 6: Lactose inhibition of galectin-1 nanoparticle formation with compound 4.
Figure 7: Cellular aggregation assays with DU145 human prostate carcinoma cells. Cancer cell aggregation assa...
Figure 8: Schematic representation of galectin-1/glycodendrimer aggregates at varying stoichiometries.